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Evidence-Based Supplement Research

Evidence-Based Supplement Research

L-Carnitine and Reduced Irritability

Doses used in studies

mg/day: 150 (median 150, IQR 150–150) — 1 study

Time to effect

Median: 13.3 months · IQR 7.8 months–18.8 months · Range 10 weeks–24.3 months — Reported in 2 of 2 studies

2 of 2 papers

l -carnitine adjunct to risperidone for treatment of autism spectrum disorder-associated behaviors: a randomized, double-blind clinical trial.
- 2023-08-07
- RCT · n = 68
- International clinical psychopharmacology 39(4)
- - Mehry Nasiri
  - Zohal Parmoon
  - Yalda Farahmand
  - Ali Moradi
  - Kimia Farahmand
  - Kamyar Moradi
  - Fatemeh A Basti
  - Mohammad-Reza Mohammadi
  - Shahin Akhondzadeh
- PubMed: 37551601
- DOI: 10.1097/yic.0000000000000496
5 Insights on
- Reduced Irritability
- High evidence
- Clinical
the combination of l-carnitine and risperidone resulted in more reduction on the irritability... (P = 0.033)
Effect
Beneficial
Effect size
Small
Significant
Yes
Dose
150 mg/day
Adding L-Carnitine and Selenium to Methimazole in Graves' Disease: A Prospective Randomized Trial on Thyroid Markers and Quality of Life.
- 2025-08-20
- RCT · n = 60
- Nutrients 17(16)
- - Mattia Rossi
  - Letizia Meomartino
  - Marco Zavattaro
  - Gloria Selvatico
  - Ruth Rossetto Giaccherino
  - Loredana Pagano
- PubMed: 40871722
- DOI: 10.3390/nu17162693
8 Insights on
- Reduced Irritability
- High evidence
- Rigorous Journal
- Clinical
the supplement exerted an independent effect in reducing the severity of irritability
Effect
Beneficial
Effect size
Small
Dose
not stated