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Evidence-Based Supplement Research

Evidence-Based Supplement Research

L-Carnitine and Reduced Malondialdehyde Level

Doses used in studies

mg/kg/day: 50 (median 50, IQR 50–50) — 1 study

Time to effect

Median: 4.3 weeks · IQR 4.3 weeks–4.3 weeks · Range 4.3 weeks–4.3 weeks — Reported in 1 of 2 studies

2 of 2 papers

Efficacy of selected dietary supplements and pharmacological agents on metabolic and oxidative stress outcomes in metabolic dysfunction-associated fatty liver disease (MAFLD): a Bayesian network meta-analysis.
- 2026-01-29
- Systematic Review · n = 273
- Frontiers in pharmacology 16
- - Yunyi Yang
  - Xiaoli He
  - Jiayuan Cai
  - Xiaoxiao Qu
  - Shufa Tan
  - Jiawen You
  - Yanming He
  - Zheng Yao
  - Hongjie Yang
- PubMed: 41695987
- DOI: 10.3389/fphar.2025.1682688
2 Insights on
- Reduced Malondialdehyde Level
- High evidence
- Clinical
whereas L-carnitine showed the most significant efficacy in suppressing lipid peroxidation
Effect
Beneficial
Effect size
Large
Significant
Yes
L-carnitine decreases myocardial injury in children undergoing open-heart surgery: A randomized controlled trial.
- 2024-04-03
- RCT · n = 60
- European journal of pediatrics 183(6)
- - Wael El Feky
  - Dalia El-Afify
  - Dina Abdelhai
  - Mohamed Elkashlan
  - Ahmed Fakhreldin
  - Doaa El Amrousy
- PubMed: 38568244
- DOI: 10.1007/s00431-024-05534-2
8 Insights on
- Reduced Malondialdehyde Level
- High evidence
- Clinical
L-carnitine group had significantly lower post-operative level of oxidative stress marker (MDA), apoptosis markers (fas and caspase-3), and myocardial injury markers (CK-MB and troponin I)
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
50 mg/kg/day once daily for 1 month before cardiac surgery