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Evidence-Based Supplement Research

Evidence-Based Supplement Research

L-Carnosine and Improved Cognitive Function

Doses used in studies

mg/day: 400–800 (median 600, IQR 400–800) — 1 study

Time to effect

Median: 5.6 months · IQR 5.6 months–5.6 months · Range 5.6 months–5.6 months — Reported in 1 of 2 studies

2 of 2 papersPopulation:

The Effects of Carnosine on Cognitive Function and Mental Health-A Systematic Review and Meta-Analysis.
- 2026-04-28
- Meta-Analysis · n = 13
- Nutrients 18(9)
- - Yung-Fang Hsiao
  - Zhongqi Fan
  - Yueh-Yin Fan
  - Mei Chung
- PubMed: 42123986
- DOI: 10.3390/nu18091385
4 Insights on
- Improved Cognitive Function
- High evidence
- Rigorous Journal
- Mixed
Results from five RCTs found no significant differences in the majority of the cognitive function measures between L-carnosine supplement and placebo
Effect
Neutral
Effect size
Small
Significant
No
Dose
not stated in abstract (dosage varied across studies)
Cognitive and negative symptoms in schizophrenia with L-Carnosine adjuvant therapy - A randomized double-blind placebo-controlled study.
- 2023-03-22
- RCT
- Pharmacology research & perspectives 11(2)
- - Hema Tharoor
  - Sindhu Maran
  - Antra K Chandan
  - Manikandan Pari
  - Shruti Rao
  - Jothilakshmi Durairaj
- PubMed: 36946070
- DOI: 10.1002/prp2.1074
4 Insights on
- Improved Cognitive Function
- High evidence
- Clinical
The attention scores (p = .023) showed significant differences... L-Carnosine dosing of 800 mg may be a promising agent to enhance executive functions in Schizophrenia.
Effect
Neutral
Effect size
Small
Significant
No
Dose
400 mg/day for first 3 months, then 800 mg/day from week 13 to week 24