L-Carnosine and Improved Response to Treatment

Doses used in studies

mg/day: 800 (median 800, IQR 800–800) — 1 study

Time to effect

Median: 6 weeks · IQR 6 weeks–6 weeks · Range 6 weeks–6 weeks — Reported in 1 of 1 study

Safety in these studies

Overall tolerabilityNo significant difference
There was no significant difference between the two groups in baseline parameters and frequency of side effects.
from: L-Carnosine combination therapy for major depressive disorder: A randomized, double-blind,

1 of 1 paper

L-Carnosine combination therapy for major depressive disorder: A randomized, double-blind, placebo-controlled trial.

2020-04
RCT
Journal of affective disorders 267
- Behin Araminia
- Mohammadreza Shalbafan
- Amirhosein Mortezaei
- Elham Shirazi
- Salomeh Ghaffari
- Erfan Sahebolzamani
- Seyyed Hosein Mortazavi
- Behnam Shariati
- Mehrdad Eftekhar Ardebili
- Ali Aqamolaei
- Sina Naderi
- Shahin Akhondzadeh

PubMed: 32063564
DOI: 10.1016/j.jad.2020.02.020

3 Insights on

Improved Response to Treatment

High evidence
Clinical

Patients in the L-Carnosine group experienced significantly greater response and remission rate than the placebo group [Ps = 0.023 and 0.012; respectively].

Effect: Beneficial
Effect size: Moderate
Significant: Yes
Dose: 400 mg twice daily