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Evidence-Based Supplement Research

Evidence-Based Supplement Research

L-Carnosine and Reduced Autism Rating Scale Score

Doses used in studies

mg/kg/day: 10–15 (median 12.5, IQR 10–15) — 1 study

Time to effect

Median: 8.6 weeks · IQR 8.6 weeks–8.6 weeks · Range 8.6 weeks–8.6 weeks — Reported in 1 of 2 studies

Safety in these studies

Overall tolerabilityReported
The secondary outcomes were improvement in sleep disorders, gastrointestinal problems, oxidative stress markers and adverse effects.
from: Effect of L-Carnosine in children with autism spectrum disorders: a systematic review and

2 of 2 papers

Effect of L-Carnosine in children with autism spectrum disorders: a systematic review and meta-analysis of randomised controlled trials.
- 2021-03-11
- Meta-Analysis · n = 215
- Amino acids 53(4)
- - Debi Ann Abraham
  - Krishna Undela
  - Udayakumar Narasimhan
  - M G Rajanandh
- PubMed: 33704575
- DOI: 10.1007/s00726-021-02960-6
8 Insights on
- Reduced Autism Rating Scale Score
- High evidence
- Clinical
Results from the meta-analysis of three studies showed no significant difference between L-Carnosine and placebo groups in ... the childhood autism rating scale (CARS) (MD = - 0.88; 95% CI - 6.96, 5.20; p = 0.78)
Effect
Neutral
Effect size
Small
Significant
No
Effect of L-Carnosine as adjunctive therapy in the management of children with autism spectrum disorder: a randomized controlled study.
- 2020-11-10
- RCT
- Amino acids 52(11-12)
- - Debi Ann Abraham
  - Udayakumar Narasimhan
  - Senta Christy
  - Rajanandh Muhasaparur Ganesan
- PubMed: 33170378
- DOI: 10.1007/s00726-020-02909-1
4 Insights on
- Reduced Autism Rating Scale Score
- High evidence
- Clinical
Supplementation of L-Carnosine did not improve the total score of CARS2-ST, ATEC, BEARS sleep screening tool and 6-GSI scores of children with ASD.
Effect
Neutral
Effect size
Small
Significant
No
Dose
10-15 mg/kg in 2 divided doses