L-Carnosine and Reduced Hyperactivity

• l-Carnosine as Adjunctive Therapy in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

  • 2018-06
  • RCT
  • Journal of child and adolescent psychopharmacology 28(5)
  • • Alireza Ghajar
    • Farinaz Aghajan-Nashtaei
    • Mohsen Afarideh
    • Mohammad-Reza Mohammadi
    • Shahin Akhondzadeh

  • PubMed: 29469593
  • DOI: 10.1089/cap.2017.0157

  6 Insights on

  • Reduced Hyperactivity

  • High evidence
  • Clinical

  Improvements in the Teacher ADHD-RS were not significantly different between the two groups in total (Greenhouse-Geisser corrected: F = 0.200, df = 1.218, p = 0.705), as well as inattention and hyperactivity subscale scores (p = 0.956 and 0.281, respectively).

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  800 mg/d in two divided doses

• l-Carnosine As an Adjunctive Therapy to Risperidone in Children with Autistic Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial.

  • 2018-02
  • RCT
  • Journal of child and adolescent psychopharmacology 28(1)
  • • Reihaneh Hajizadeh-Zaker
    • Alireza Ghajar
    • Bita Mesgarpour
    • Mohsen Afarideh
    • Mohammad-Reza Mohammadi
    • Shahin Akhondzadeh

  • PubMed: 29027815
  • DOI: 10.1089/cap.2017.0026

  5 Insights on

  • Reduced Hyperactivity

  • High evidence
  • Clinical

  Significant effect was detected on the hyperactivity/noncompliance subscale [F (1.62, 64.96) = 3.53, p-value = 0.044]. Significantly greater score reduction in the hyperactivity/noncompliance subscale occurred in the l-carnosine group compared with the placebo group at the end of the trial.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  800 mg/day in 2 divided doses