L-carnosine as an add-on to risperidone for treatment of negative symptoms in patients with stable schizophrenia: A double-blind, randomized placebo-controlled trial.
- 2018-04
- RCT
- Psychiatry research 262
- Alireza Ghajar
- Mohammad-Reza Khoaie-Ardakani
- Zahara Shahmoradi
- Amir-Reza Alavi
- Mohsen Afarideh
- Mohammad-Reza Shalbafan
- Maryam Ghazizadeh-Hashemi
- Shahin Akhondzadeh
- PubMed: 29427913
- DOI: 10.1016/j.psychres.2018.02.012
- High evidence
- Clinical
L-carnosine resulted in greater improvement of negative scores as well as total PANSS scores but not positive subscale scores compared to placebo.
- Effect
- Beneficial
- Effect size
- Moderate
- Significant
- Yes
- Dose
- 2 gr/day in two divided doses