L-Carnosine protects against Oxaliplatin-induced peripheral neuropathy in colorectal cancer patients: A perspective on targeting Nrf-2 and NF-κB pathways.
- 2019-02
- RCT · n = 65
- Toxicology and applied pharmacology 365
- Rana Yehia
- Samira Saleh
- Hanan El Abhar
- Amr S Saad
- Mona Schaalan
- PubMed: 30592963
- DOI: 10.1016/j.taap.2018.12.015
- High evidence
- Clinical
The neuropathy grading evaluation of Arm B vs Arm A revealed that 17 patients (56.7%) vs 11 patients (35.5%) suffered grade 1, one patient (3.3%) vs 19 patients (61.3%) suffered grade 2, while 12 patients (40%) vs one patient (3.2%) were normal.
- Effect
- Beneficial
- Effect size
- Large
- Significant
- Yes
- Dose
- 500 mg/day