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Evidence-Based Supplement Research

Evidence-Based Supplement Research

L-Citrulline and Improved 6-minute Walking Distance

Doses used in studies

g/day: 15 (median 15, IQR 15–15) — 1 study

Time to effect

Median: 5.6 months · IQR 5.6 months–5.6 months · Range 5.6 months–5.6 months — Reported in 1 of 1 study

Safety in these studies

Overall tolerabilityReported
L-Citrulline was safe and well tolerated.
from: Treatment with L-Citrulline in patients with post-polio syndrome: A single center, randomi

1 of 1 paper

Treatment with L-Citrulline in patients with post-polio syndrome: A single center, randomized, double blind, placebo-controlled trial.
- 2021-11
- RCT
- Neuromuscular disorders : NMD 31(11)
- - Niveditha Putananickal
  - Anna-Lena Orsini
  - Simone Schmidt
  - Vanya Gocheva
  - Daniela Rubino
  - Tanja Haas
  - Sabine Schädelin
  - Xeni Deligianni
  - Oliver Bieri
  - Dirk Fischer
  - Patricia Hafner
- PubMed: 34711479
- DOI: 10.1016/j.nmd.2021.08.011
3 Insights on
- Improved 6-minute Walking Distance
- High evidence
- Clinical
Patients receiving L-Citrulline walked 17.5 longer in the 6 min walking distance test when compared to placebo group, however not statistically significant (95% CI = -14.69; 49.68, p = 0.298)
Effect
Neutral
Effect size
Small
Significant
No
Dose
15 g/day