L-Citrulline and Improved 6-minute Walking Distance

• Effect of L-Citrulline Supplementation on Endothelial Function and Body Composition in Post-COVID-19 Syndrome: A Randomized Clinical Trial.

  • 2026-05-27
  • RCT · n = 43
  • Nutrients 18(11)
  • • Salgado-Fernández María Fernanda
    • Orea-Tejeda Arturo
    • Sierra-Vargas Martha Patricia
    • González-Islas Dulce
    • Debray-García Yazmín
    • Aztatzi-Aguilar Octavio Gamaliel
    • Galicia-Amor Susana
    • Hernández-López Samantha
    • Renteria-Serralde Getsemani
    • Cruz-Gijón Gabriela
    • Maldonado-Vargas Valeria

  • PubMed: 42280350
  • DOI: 10.3390/nu18111706

  6 Insights on

  • Improved 6-minute Walking Distance

  • High evidence
  • Rigorous Journal
  • Clinical

  increase in 6MWT (141.2 m; 95% CI: 98.40 to 184 vs. 67.70 m, CI 95%: 30.62 to 104.78, p = 0.011)

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes

  Dose

  4 g/day

• Treatment with L-Citrulline in patients with post-polio syndrome: A single center, randomized, double blind, placebo-controlled trial.

  • 2021-11
  • RCT
  • Neuromuscular disorders : NMD 31(11)
  • • Niveditha Putananickal
    • Anna-Lena Orsini
    • Simone Schmidt
    • Vanya Gocheva
    • Daniela Rubino
    • Tanja Haas
    • Sabine Schädelin
    • Xeni Deligianni
    • Oliver Bieri
    • Dirk Fischer
    • Patricia Hafner

  • PubMed: 34711479
  • DOI: 10.1016/j.nmd.2021.08.011

  3 Insights on

  • Improved 6-minute Walking Distance

  • High evidence
  • Clinical

  Patients receiving L-Citrulline walked 17.5 longer in the 6 min walking distance test when compared to placebo group, however not statistically significant (95% CI = -14.69; 49.68, p = 0.298)

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  15 g/day