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Evidence-Based Supplement Research

Evidence-Based Supplement Research

L-Citrulline and Improved Forced Vital Capacity

Doses used in studies

g/day: 6–15 (median 10.5, IQR 8.25–12.75) — 2 studies

Time to effect

Median: 11 days · IQR 9 days–12 days · Range 7 days–2 weeks — Reported in 2 of 2 studies

2 of 2 papersPopulation:

Short-Term L-Citrulline Supplementation Does Not Affect Inspiratory Muscle Oxygenation and Respiratory Performance in Older Adults.
- 2023-04-18
- RCT
- Nutrients 15(8)
- - Anastasios A Theodorou
  - Panagiotis N Chatzinikolaou
  - Nikos V Margaritelis
  - Filippos Christodoulou
  - Themistoklis Tsatalas
  - Vassilis Paschalis
- PubMed: 37111169
- DOI: 10.3390/nu15081951
9 Insights on
- Improved Forced Vital Capacity
- High evidence
- Rigorous Journal
- Elderly
Pulmonary function, MIP, rate of perceived exertion, and sternocleidomastoid muscle oxygenation were not affected by the L-citrulline supplementation.
Effect
Neutral
Effect size
Small
Significant
No
Dose
6 g/day
L-Citrulline increases nitric oxide and improves control in obese asthmatics.
- 2019-12-19
- RCT · n = 41
- JCI insight 4(24)
- - Fernando Holguin
  - Hartmut Grasemann
  - Sunita Sharma
  - Daniel Winnica
  - Karen Wasil
  - Vong Smith
  - Margaret H Cruse
  - Nancy Perez
  - Erika Coleman
  - Timothy J Scialla
  - Loretta G Que
- PubMed: 31714895
- DOI: 10.1172/jci.insight.131733
4 Insights on
- Improved Forced Vital Capacity
- High evidence
- Clinical
the forced vital capacity ... changed by 86 ml (10-161 ml)
Effect
Beneficial
Effect size
Small
Significant
Yes
Dose
15 g/day