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Evidence-Based Supplement Research

Evidence-Based Supplement Research

L-Citrulline and Improved Maximal Inspiratory Pressure

Doses used in studies

g/day: 6 (median 6, IQR 6–6) — 2 studies

Time to effect

Median: 7 days · IQR 7 days–7 days · Range 7 days–7 days — Reported in 1 of 2 studies

2 of 2 papersPopulation:

Short-Term L-Citrulline Supplementation Does Not Affect Inspiratory Muscle Oxygenation and Respiratory Performance in Older Adults.
- 2023-04-18
- RCT
- Nutrients 15(8)
- - Anastasios A Theodorou
  - Panagiotis N Chatzinikolaou
  - Nikos V Margaritelis
  - Filippos Christodoulou
  - Themistoklis Tsatalas
  - Vassilis Paschalis
- PubMed: 37111169
- DOI: 10.3390/nu15081951
9 Insights on
- Improved Maximal Inspiratory Pressure
- High evidence
- Rigorous Journal
- Elderly
Pulmonary function, MIP, rate of perceived exertion, and sternocleidomastoid muscle oxygenation were not affected by the L-citrulline supplementation.
Effect
Neutral
Effect size
Small
Significant
No
Dose
6 g/day
Acute L-Citrulline Supplementation Increases Nitric Oxide Bioavailability but Not Inspiratory Muscle Oxygenation and Respiratory Performance.
- 2021-09-22
- Clinical Trial
- Nutrients 13(10)
- - Anastasios A Theodorou
  - Panagiotis T Zinelis
  - Vassiliki J Malliou
  - Panagiotis N Chatzinikolaou
  - Nikos V Margaritelis
  - Dimitris Mandalidis
  - Nickos D Geladas
  - Vassilis Paschalis
- PubMed: 34684312
- DOI: 10.3390/nu13103311
5 Insights on
- Improved Maximal Inspiratory Pressure
- High evidence
- Rigorous Journal
- Adults
Pulmonary function and MIP were not affected by the L-citrulline supplementation.
Effect
Neutral
Effect size
Small
Significant
No
Dose
6 g