Improved vascular function and functional capacity following l-citrulline administration in patients with heart failure with preserved ejection fraction: a single-arm, open-label, prospective pilot study.
- 2023-02-01
- Clinical Trial · n = 14
- Journal of applied physiology (Bethesda, Md. : 1985) 134(2)
- Stephen M Ratchford
- Kanokwan Bunsawat
- Jeremy K Alpenglow
- Jia Zhao
- Josephine B Wright
- John J Ryan
- D Walter Wray
- PubMed: 36476159
- DOI: 10.1152/japplphysiol.00445.2022
- Moderate evidence
- Clinical
7 days of l-Cit administration improved ... RH (0d: 468 ± 167 mL, 7d: 577 ± 199 mL)
- Effect
- Beneficial
- Effect size
- Moderate
- Significant
- Yes
- Dose
- 6 g/day