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Evidence-Based Supplement Research

Evidence-Based Supplement Research

L-Citrulline and Increased Arginine Level

Doses used in studies

mg/kg/day: 100–300 (median 200, IQR 100–300) — 1 study

Time to effect

Median: 7 days · IQR 7 days–7 days · Range 7 days–7 days — Reported in 1 of 1 study

Safety in these studies

Overall tolerabilityReported
A total of 40/42 (95%) of the recruits completed the 7-day supplementation with no adverse events.
from: Enteral L-citrulline supplementation in preterm infants is safe and effective in increasin

1 of 1 paper

Enteral L-citrulline supplementation in preterm infants is safe and effective in increasing plasma arginine and citrulline levels-a pilot randomized trial.
- 2023-08-28
- RCT · n = 40
- Journal of perinatology : official journal of the California Perinatal Association 44(5)
- - Amna Qasim
  - Mohammad Q Mehdi
  - Snigdha Bhatia
  - Maria E Franco-Fuenmayor
  - Sunil K Jain
- PubMed: 37640809
- DOI: 10.1038/s41372-023-01761-x
2 Insights on
- Increased Arginine Level
- High evidence
- Infants
plasma-arginine levels increased significantly in the high-dose group
Effect
Beneficial
Effect size
Small
Significant
Yes
Dose
100 mg/kg/day, 200 mg/kg/day, 300 mg/kg/day