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Evidence-Based Supplement Research

Evidence-Based Supplement Research

L-Citrulline and Increased Nitric Oxide Metabolite Level

Doses used in studies

g/day: 8 (median 8, IQR 8–8) — 1 study

Time to effect

Median: 5 weeks · IQR 4.5 weeks–5.5 weeks · Range 4 weeks–6 weeks — Reported in 2 of 2 studies

2 of 2 papers

Effects of Quercetin and Citrulline on Nitric Oxide Metabolites and Antioxidant Biomarkers in Trained Cyclists.
- 2025-01-09
- RCT
- Nutrients 17(2)
- - Jennifer A Kurtz
  - Rafaela G Feresin
  - Jacob Grazer
  - Jeff Otis
  - Kathryn E Wilson
  - J Andrew Doyle
  - Kevin A Zwetsloot
- PubMed: 39861353
- DOI: 10.3390/nu17020224
4 Insights on
- Increased Nitric Oxide Metabolite Level
- High evidence
- Rigorous Journal
- Athletes
NO metabolites were significantly elevated post-supplementation (p = 0.03)
Effect
Beneficial
Effect size
Small
Significant
Yes
Dose
not specified
Changes in resistance training performance, rating of perceived exertion, and blood biomarkers after six weeks of supplementation with L-citrulline vs. L-citrulline DL-malate in resistance-trained men: a double-blind placebo-controlled trial.
- 2025-06-05
- RCT
- Journal of the International Society of Sports Nutrition 22(1)
- - Davoud Bayat
  - Mohammad Azizi
  - Naser Behpour
  - Grant M Tinsley
- PubMed: 40470618
- DOI: 10.1080/15502783.2025.2513944
7 Insights on
- Increased Nitric Oxide Metabolite Level
- High evidence
- Athletes
A significant time effect for NOX was detected only for LC (p = 0.014) and CM (p = 0.003). In addition, a marginally significant difference between LC and PL (p = 0.057) was detected regarding post-exercise NOX values at post-intervention.
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
8 g