Skip to main content

Evidence-Based Supplement Research

Evidence-Based Supplement Research

L-Citrulline and Increased Testosterone Level

Doses used in studies

g/day: 6 (median 6, IQR 6–6) — 1 study

Time to effect

Median: 5 weeks · IQR 4.5 weeks–5.5 weeks · Range 4 weeks–6 weeks — Reported in 2 of 2 studies

2 of 2 papersPopulation:

L-Citrulline Supplementation and Exercise in the Management of Sarcopenia.
- 2021-09-08
- RCT · n = 44
- Nutrients 13(9)
- - Alberto Caballero-García
  - Jorge Pascual-Fernández
  - David César Noriega-González
  - Hugo J Bello
  - Antoni Pons-Biescas
  - Enrique Roche
  - Alfredo Córdova-Martínez
- PubMed: 34579009
- DOI: 10.3390/nu13093133
7 Insights on
- Increased Testosterone Level
- High evidence
- Rigorous Journal
- Elderly
Markers of muscle damage as well as circulating levels of testosterone, cortisol and vitamin D showed no significant changes, but a tendency to improve at the end of intervention in the supplemented group compared to placebo
Effect
Neutral
Effect size
Small
Significant
No
Dose
not stated
Combined Vs. Single Supplementation of L-Citrulline and Sodium Bicarbonate During Sprint Interval Training in Basketball Players: Effects on Physical Performance and Hormonal Adaptations.
- 2025-06-01
- RCT
- Journal of sports science & medicine 24(2)
- - Yongliang Wang
  - Yanyan Wang
  - Kun Qian
- PubMed: 40469872
- DOI: 10.52082/jssm.2025.258
7 Insights on
- Increased Testosterone Level
- High evidence
- Athletes
no significant (p > 0.05) changes were seen in testosterone
Effect
Neutral
Effect size
Small
Significant
No
Dose
6 g daily