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Evidence-Based Supplement Research

Evidence-Based Supplement Research

L-Citrulline and Reduced Aortic Pulse Pressure

Doses used in studies

g/day: 6–10 (median 8, IQR 7–9) — 2 studies

Time to effect

Median: 3 weeks · IQR 2.5 weeks–3.5 weeks · Range 2 weeks–4 weeks — Reported in 2 of 2 studies

2 of 2 papersPopulation:

L-Citrulline supplementation attenuates aortic pulse pressure and wave reflection responses to cold stress in older adults.
- 2022-03
- RCT
- Experimental gerontology 159
- - Salvador J Jaime
  - Jessica Nagel
  - Arun Maharaj
  - Stephen M Fischer
  - Elizabeth Schwab
  - Christopher Martinson
  - Kim Radtke
  - Richard P Mikat
  - Arturo Figueroa
- PubMed: 34990772
- DOI: 10.1016/j.exger.2021.111685
8 Insights on
- Reduced Aortic Pulse Pressure
- High evidence
- Elderly
Although no hemodynamic changes at rest
Effect
Neutral
Effect size
Small
Significant
No
Dose
6 g/day
L-Citrulline supplementation attenuates aortic pressure and pressure waves during metaboreflex activation in postmenopausal women.
- 2023-09-04
- RCT
- The British journal of nutrition 131(3)
- - Katherine N Dillon
  - Yejin Kang
  - Arun Maharaj
  - Mauricio A Martinez
  - Stephen M Fischer
  - Arturo Figueroa
- PubMed: 37664994
- DOI: 10.1017/s000711452300199x
4 Insights on
- Reduced Aortic Pulse Pressure
- High evidence
- Clinical
CIT attenuated ΔPP (−5 ± 2 v. 0 ± 1 mmHg, P = 0·03)
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
10 g/d