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Evidence-Based Supplement Research

Evidence-Based Supplement Research

L-Citrulline and Reduced Arterial Stiffness

Doses used in studies

g/day: 6 (median 6, IQR 6–6) — 1 study

Time to effect

Median: 4 weeks · IQR 4 weeks–4 weeks · Range 4 weeks–4 weeks — Reported in 1 of 2 studies

Safety in these studies

Overall tolerabilityReported
Across all studies, no adverse effects related to citrulline supplementation were reported.
from: Citrulline supplementation in postmenopausal women: a systematic review of vascular, muscu

2 of 2 papersPopulation:

Citrulline supplementation in postmenopausal women: a systematic review of vascular, muscular, and metabolic effects.
- 2026-01-26
- Systematic Review
- BMC women's health 26(1)
- - Hossein Bahari
  - Elmira Ramezani
  - Mahsa Malekahmadi
- PubMed: 41588439
- DOI: 10.1186/s12905-026-04277-6
9 Insights on
- Reduced Arterial Stiffness
- High evidence
- Elderly
Five studies examined arterial stiffness, with mixed findings on pulse wave velocity and augmentation index
Effect
Neutral
Effect size
Small
Significant
No
Dose
not specified in abstract
Effects of L-Citrulline Supplementation on Endothelial Function, Arterial Stiffness, and Blood Glucose Level in the Fasted and Acute Hyperglycemic States in Middle-Aged and Older Adults with Type 2 Diabetes.
- 2025-11-28
- RCT · n = 16
- Nutrients 17(23)
- - Yejin Kang
  - Katherine N Dillon
  - Danielle E Levitt
  - Arturo Figueroa
- PubMed: 41374029
- DOI: 10.3390/nu17233739
4 Insights on
- Reduced Arterial Stiffness
- High evidence
- Rigorous Journal
- Clinical
Four weeks of L-citrulline supplementation improved... femoral-ankle PWV... in the fasted state compared to placebo (all p < 0.05). During acute hyperglycemia, CIT supplementation... reduced femoral-ankle PWV... compared to placebo (all p < 0.05).
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
6 g/day