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Evidence-Based Supplement Research

Evidence-Based Supplement Research

L-Citrulline and Reduced Augmentation Index

Doses used in studies

g/day: 6 (median 6, IQR 6–6) — 1 study

Time to effect

Median: 7 weeks · IQR 4.5 weeks–9.5 weeks · Range 2 weeks–2.8 months — Reported in 2 of 2 studies

2 of 2 papersPopulation:

Impact of L-Citrulline Supplementation and HIIT on Lipid Profile, Arterial Stiffness, and Fat Mass in Obese Adolescents with Metabolic-Dysfunction-Associated Fatty Liver Disease: A Randomized Clinical Trial.
- 2025-01-23
- RCT · n = 15
- Nutrients 17(3)
- - Alan Arturo Rodríguez-Carrillo
  - Mario Ramón Espinoza-Vargas
  - Katya Vargas-Ortiz
  - Lorena Del Rocío Ibarra-Reynoso
  - Monserrat Olvera-Juárez
  - Armando Gómez-Ojeda
  - Ma Eugenia Garay-Sevilla
  - Arturo Figueroa
- PubMed: 39940261
- DOI: 10.3390/nu17030402
9 Insights on
- Reduced Augmentation Index
- High evidence
- Rigorous Journal
- Clinical
No significant between-group changes were found in ... AIx75
Effect
Neutral
Effect size
Small
Significant
No
Dose
not specified
L-Citrulline supplementation attenuates aortic pulse pressure and wave reflection responses to cold stress in older adults.
- 2022-03
- RCT
- Experimental gerontology 159
- - Salvador J Jaime
  - Jessica Nagel
  - Arun Maharaj
  - Stephen M Fischer
  - Elizabeth Schwab
  - Christopher Martinson
  - Kim Radtke
  - Richard P Mikat
  - Arturo Figueroa
- PubMed: 34990772
- DOI: 10.1016/j.exger.2021.111685
8 Insights on
- Reduced Augmentation Index
- High evidence
- Elderly
AIx@75 (Δ-3.2 ± 7.2 vs. Δ2.2 ± 6.9%; P = 0.038) ... responses to the CPT were significantly attenuated following L-CIT supplementation vs. placebo.
Effect
Beneficial
Effect size
Small
Significant
Yes
Dose
6 g/day