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Evidence-Based Supplement Research

Evidence-Based Supplement Research

L-Citrulline and Reduced Blood Glucose Level

Doses used in studies

g/day: 6 (median 6, IQR 6–6) — 1 study

Time to effect

Median: 4 weeks · IQR 4 weeks–4 weeks · Range 4 weeks–4 weeks — Reported in 1 of 2 studies

2 of 2 papersPopulation:

Effects of L-Citrulline Supplementation on Endothelial Function, Arterial Stiffness, and Blood Glucose Level in the Fasted and Acute Hyperglycemic States in Middle-Aged and Older Adults with Type 2 Diabetes.
- 2025-11-28
- RCT · n = 16
- Nutrients 17(23)
- - Yejin Kang
  - Katherine N Dillon
  - Danielle E Levitt
  - Arturo Figueroa
- PubMed: 41374029
- DOI: 10.3390/nu17233739
4 Insights on
- Reduced Blood Glucose Level
- High evidence
- Rigorous Journal
- Clinical
Four weeks of L-citrulline supplementation improved... blood glucose concentration in the fasted state compared to placebo (all p < 0.05). During acute hyperglycemia, CIT supplementation... reduced glucose levels compared to placebo (all p < 0.05).
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
6 g/day
Metabolic effects of L-citrulline in type 2 diabetes.
- 2023-01-25
- Review
- Acta physiologica (Oxford, England) 237(3)
- - Fatemeh Bagheripour
  - Sajad Jeddi
  - Khosrow Kashfi
  - Asghar Ghasemi
- PubMed: 36645144
- DOI: 10.1111/apha.13937
8 Insights on
- Reduced Blood Glucose Level
- Low evidence
Cit supplementation in T2D increases circulating levels of Cit and L-arginine while decreasing circulating glucose and free fatty acids and improving dyslipidemia.
Effect
Beneficial
Effect size
Small
Significant
Yes