L-Citrulline and Reduced Muscle Degeneration

• Treatment with L-Citrulline in patients with post-polio syndrome: A single center, randomized, double blind, placebo-controlled trial.

  • 2021-11
  • RCT
  • Neuromuscular disorders : NMD 31(11)
  • • Niveditha Putananickal
    • Anna-Lena Orsini
    • Simone Schmidt
    • Vanya Gocheva
    • Daniela Rubino
    • Tanja Haas
    • Sabine Schädelin
    • Xeni Deligianni
    • Oliver Bieri
    • Dirk Fischer
    • Patricia Hafner

  • PubMed: 34711479
  • DOI: 10.1016/j.nmd.2021.08.011

  3 Insights on

  • Reduced Muscle Degeneration

  • High evidence
  • Clinical

  Muscle degeneration of leg muscles assessed with quantitative MRI indicated no significant change (estimate= -0.01, 95% CI =-0.13; 0.11, p = 0.869)

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  15 g/day