L-Citrulline and Reduced Stroke-Like Episode Severity

• Diagnostic Criteria and Management of MELAS and Stroke-Like Episodes: Consensus-Based Statements.

  • 2026-04
  • Systematic Review
  • European journal of neurology 33(4)
  • • Michelangelo Mancuso
    • Marcello Bellusci
    • Valerio Carelli
    • Irenaeus de Coo
    • Daria Diodato
    • Felix Distelmaier
    • Omar Hikmat
    • Michio Hirano
    • Rita Horvath
    • Amel Karaa
    • Thomas Klopstock
    • Mary Kay Koenig
    • Cornelia Kornblum
    • Chiara La Morgia
    • Piervito Lopriore
    • Mika Henrik Martikainen
    • Robert McFarland
    • Olimpia Musumeci
    • Robert D S Pitceathly
    • Guido Primiano
    • Shamima Rahman
    • Fernando Scaglia
    • Andrew Schaefer
    • Manuel Schiff
    • Luisa Semmler
    • Costanza Lamperti
    • Serenella Servidei

  • PubMed: 41999163
  • DOI: 10.1111/ene.70588

  1 Insight on

  • Reduced Stroke-Like Episode Severity

  • High evidence
  • Mixed

  The panel agreed that the efficacy of L-arginine, L-taurine, L-citrulline, coenzyme Q10, vitamins, and other supplements remains unproven and requires validation in clinical trials.

  Effect

  Neutral

  Effect size

  Small

  Significant

  No