L-Citrulline and Reduced Systolic Blood Pressure

• Does l-citrulline supplementation and watermelon intake reduce blood pressure in middle-aged and older adults? A systematic review and meta-analysis of randomized controlled trials.

  • 2025-10
  • Meta-Analysis · n = 415
  • Clinical nutrition ESPEN 69
  • • Ping Luo
    • Jingfeng Chen
    • Kang Liu
    • Jia Zhang

  • PubMed: 40789388
  • DOI: 10.1016/j.clnesp.2025.07.1130

  2 Insights on

  • Reduced Systolic Blood Pressure

  • High evidence
  • Elderly

  Subgroup analysis showed that the combined supplementation of l-citrulline and l-arginine significantly decreased SBP (-10.44 mmHg [95 % CI: -13.57 to -7.31], P < 0.00001)

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes

• Citrulline supplementation in postmenopausal women: a systematic review of vascular, muscular, and metabolic effects.

  • 2026-01-26
  • Systematic Review
  • BMC women's health 26(1)
  • • Hossein Bahari
    • Elmira Ramezani
    • Mahsa Malekahmadi

  • PubMed: 41588439
  • DOI: 10.1186/s12905-026-04277-6

  9 Insights on

  • Reduced Systolic Blood Pressure

  • High evidence
  • Elderly

  Citrulline supplementation may offer benefits for blood pressure regulation (up to 9 mmHg SBP reduction in some studies) in hypertensive postmenopausal women

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  not specified in abstract