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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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L-Citrulline and Reduced Systolic Blood Pressure

Research synthesisVery low evidenceLarge effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across all 3 studies in the database, L-Citrulline supplementation was associated with beneficial reductions in systolic blood pressure, with effect sizes ranging from moderate to large. A 2025 meta-analysis reported a statistically significant large effect of -10.44 mmHg (95% CI: -13.57 to -7.31) in middle-aged and elderly individuals. However, the evidence base is very small (only 3 studies), and no consistent dose, form, or study duration data were reported across studies.

  • Studied populations: middle-aged and elderly individuals, postmenopausal women

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Doses, forms, and study durations were not consistently reported, limiting ability to generalize findings.

Generated Jul 13, 2026
Safety in these studies
3 of 3 papers
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