L-Glutamic Acid and Reduced Vaso-Occlusive Crisis Severity

• The Role of Non-genetic Therapies to Reduce the Incidence of Sickle Cell Crisis: A Systematic Review.

  • 2023-08-01
  • Review
  • Cureus 15(8)
  • • Shravya Pingili
    • Vijaya Krishna Makkena
    • Arturo P Jaramillo
    • Babatope L Awosusi
    • Javaria Ayyub
    • Karan Nareshbhai Dabhi
    • Namra V Gohil
    • Nida Tanveer
    • Sally Hussein
    • Pousette Hamid

  • PubMed: 37664256
  • DOI: 10.7759/cureus.42785

  3 Insights on

  • Reduced Vaso-Occlusive Crisis Severity

  • Low evidence
  • Clinical

  Voxelotor, crizanlizumab, L-glutamate, long-term blood transfusions, Zinc (Zn), Niprisan®, and Ciklavit* were found to reduce the number and severity of VOC.

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes