L-Glutamine and Improved Cerebral Blood Flow Velocity

Doses used in studies

g/kg/day: 0.3 (median 0.3, IQR 0.3–0.3) — 1 study

Time to effect

Median: 5.6 months · IQR 5.6 months–5.6 months · Range 5.6 months–5.6 months — Reported in 1 of 1 study

1 of 1 paper

Safety and efficacy of L-Glutamine in reducing the frequency of acute complications among patients with sickle cell disease: A randomized controlled study.

2024-07-19
RCT
Annals of hematology 103(9)
- Fatma Soliman Elsayed Ebeid
- Nihal Hussien Aly
- Naglaa Mohammed Shaheen
- Samah Mohammed Ahmed Abdellatif
- Ahmed Ashraf Mahmoud Okba
- Nada Ayman Gad
- Sara Mostafa Makkeyah

PubMed: 39028356
DOI: 10.1007/s00277-024-05877-8

3 Insights on

Improved Cerebral Blood Flow Velocity

High evidence
Clinical

Time-averaged mean maximum velocity for the glutamine group had a marginal increase in both middle cerebral arteries ... and in both internal carotid arteries, values increased from abnormally low to normal ranges at week 24

Effect: Beneficial
Effect size: Small
Dose: 0.3 gm/kg/dose/12h