L-Glutamine and Improved Quality of Life

• L-arginine vs. L-glutamine oral suspensions for radiation-induced oral mucositis: a triple-blind randomized trial.

  • 2025-07-03
  • RCT · n = 23
  • Journal of cancer research and clinical oncology 151(7)
  • • Fatma E A Hassanein
    • Christine Mikhail
    • Sarah Elkot
    • Asmaa Abou-Bakr

  • PubMed: 40603739
  • DOI: 10.1007/s00432-025-06213-x

  4 Insights on

  • Improved Quality of Life

  • High evidence
  • Clinical

  OHIP-14 scores improved significantly in the arginine and glutamine groups at weeks 5 and 7 (p < 0.001).

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes

  Dose

  5 g

• Effects of L-glutamine and hyaluronic acid associated with photobiomodulation on oral mucositis: a randomized clinical trial.

  • 2025-04-28
  • RCT · n = 24
  • Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 33(5)
  • • Rodrigo Wilmes Dos Santos
    • Allisson Filipe Lopes Martins
    • Sebastião Silvério Sousa-Neto
    • Marília Oliveira Morais
    • Victor Hugo Lopes de Oliveira Moreira
    • Diego Antonio Costa Arantes
    • Angélica Ferreira Oton-Leite
    • Nilceana Maya Aires Freitas
    • Cláudio Rodrigues Leles
    • Elismauro Francisco Mendonça

  • PubMed: 40295318
  • DOI: 10.1007/s00520-025-09480-z

  2 Insights on

  • Improved Quality of Life

  • High evidence
  • Clinical

  The impact of oral health on quality of life and the symptoms reported by patients were lower in group B at all times evaluated.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes