L-Glutamine and Reduced Oral Mucositis

• The Efficacy and Safety of Nutritional Supplements for Cancer Supportive Care: An Umbrella Review and Hierarchical Evidence Synthesis.

  • 2026-01
  • Systematic Review
  • Integrative cancer therapies 25
  • • Sarah Benna-Doyle
    • Suzanne Grant
    • Alison Maunder
    • Jing Liu
    • Melik Ibrahim
    • Adele Cave
    • Chhiti Pandey
    • Monica Tang
    • Eng-Siew Koh
    • Geoff Delaney
    • Deep Jyoti Bhuyan
    • Victoria Choi
    • Ki Kwon
    • Maria Gonzalez
    • Susannah Graham
    • Ashanya Malalasekera
    • Carolyn Ee

  • PubMed: 41482855
  • DOI: 10.1177/15347354251405267

  13 Insights on

  • Reduced Oral Mucositis

  • High evidence

  There was low to very low certainty evidence that glutamine, zinc, probiotics and melatonin may be effective for oral mucositis

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

• Adjunctive Treatments for the Prevention of Chemotherapy- and Radiotherapy-Induced Mucositis.

  • 2018-08-23
  • Review
  • Integrative cancer therapies 17(4)
  • • Michael Thomsen
    • Luis Vitetta

  • PubMed: 30136590
  • DOI: 10.1177/1534735418794885

  6 Insights on

  • Reduced Oral Mucositis

  • Moderate evidence
  • Highly Cited

  Zinc, glutamine, and topical vitamin E were demonstrated efficacy for oral mucositis.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  topical