L-Glutamine and Reduced Oral Mucositis Severity

• L-arginine vs. L-glutamine oral suspensions for radiation-induced oral mucositis: a triple-blind randomized trial.

  • 2025-07-03
  • RCT · n = 23
  • Journal of cancer research and clinical oncology 151(7)
  • • Fatma E A Hassanein
    • Christine Mikhail
    • Sarah Elkot
    • Asmaa Abou-Bakr

  • PubMed: 40603739
  • DOI: 10.1007/s00432-025-06213-x

  4 Insights on

  • Reduced Oral Mucositis Severity

  • High evidence
  • Clinical

  WHO scale scores differed significantly among groups (p < 0.001), with arginine and glutamine groups exhibiting lower mucositis severity than the maltodextrin group.

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes

  Dose

  5 g

• Update on the treatment of chemotherapy and radiotherapy-induced buccal mucositis: a systematic review.

  • 2023-04-29
  • Systematic Review
  • Acta odontologica latinoamericana : AOL 36(1)
  • • Schilin Wen
    • Leonardo Brito
    • Javiera Santander
    • Gonzalo Conteras

  • PubMed: 37314054
  • DOI: 10.54589/aol.36/1/3

  1 Insight on

  • Reduced Oral Mucositis Severity

  • High evidence
  • Clinical

  Dentoxol mouthwashes, Plantago major extract, thyme honey extract, zinc oxide paste, vitamin B complex combined with GeneTime, and the consumption of L-glutamine are effective in diminishing the severity of OM.

  Effect

  Beneficial

  Effect size

  Moderate

• Effects of L-glutamine and hyaluronic acid associated with photobiomodulation on oral mucositis: a randomized clinical trial.

  • 2025-04-28
  • RCT · n = 24
  • Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 33(5)
  • • Rodrigo Wilmes Dos Santos
    • Allisson Filipe Lopes Martins
    • Sebastião Silvério Sousa-Neto
    • Marília Oliveira Morais
    • Victor Hugo Lopes de Oliveira Moreira
    • Diego Antonio Costa Arantes
    • Angélica Ferreira Oton-Leite
    • Nilceana Maya Aires Freitas
    • Cláudio Rodrigues Leles
    • Elismauro Francisco Mendonça

  • PubMed: 40295318
  • DOI: 10.1007/s00520-025-09480-z

  2 Insights on

  • Reduced Oral Mucositis Severity

  • High evidence
  • Clinical

  The combination of PBM + POCP + L-G + HA resulted in a significantly lower severity of OM than PBM + POCP alone, according to the WHO scale at the 30th RT.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes