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L-Glutamine and Reduced Pain Crises

Doses used in studies
  • g/kg/day: 0.6 (median 0.6, IQR 0.6–0.6) — 1 study
Time to effect
Median: 11.2 months · IQR 11.2 months–11.2 months · Range 11.2 months–11.2 months — Reported in 1 of 1 study
Safety in these studies
1 of 1 paper

  • A Phase 3 Trial of l-Glutamine in Sickle Cell Disease.

    • 2018-07-19
    • RCT · n = 230
    • The New England journal of medicine 379(3)
      • Yutaka Niihara
      • Scott T Miller
      • Julie Kanter
      • Sophie Lanzkron
      • Wally R Smith
      • Lewis L Hsu
      • Victor R Gordeuk
      • Kusum Viswanathan
      • Sharada Sarnaik
      • Ifeyinwa Osunkwo
      • Edouard Guillaume
      • Swayam Sadanandan
      • Lance Sieger
      • Joseph L Lasky
      • Eduard H Panosyan
      • Osbourne A Blake
      • Tamara N New
      • Rita Bellevue
      • Lan T Tran
      • Rafael L Razon
      • Charles W Stark
      • Lynne D Neumayr
      • Elliott P Vichinsky
    2 Insights on
    • High evidence
    • Large Human Trial
    • Highly Cited
    • Clinical

    The patients in the l-glutamine group had significantly fewer pain crises than those in the placebo group (P=0.005), with a median of 3.0 in the l-glutamine group and 4.0 in the placebo group.

    Effect
    Beneficial
    Effect size
    Moderate
    Significant
    Yes
    Dose
    0.3 g per kilogram of body weight per dose twice daily
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