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Evidence-Based Supplement Research

Evidence-Based Supplement Research

L-Glutamine and Reduced Vaso-Occlusive Crisis Frequency

Doses used in studies

g/kg/day: 0.3 (median 0.3, IQR 0.3–0.3) — 1 study

Time to effect

Median: 5.8 months · IQR 5.7 months–5.9 months · Range 5.6 months–6 months — Reported in 2 of 2 studies

2 of 2 papers

The GLOBE Trial: Efficacy and Safety of L-Glutamine Plus Hydroxyurea Versus Hydroxyurea Alone in Sickle Cell Anemia - A Double-Blind, Randomized Study
- 2026-02-10
- RCT · n = 53
- Turkish journal of haematology : official journal of Turkish Society of Haematology 43(2)
- - Nader Shakibazad
  - Moslem Momenzadeh
  - Batool Amiri
  - Marzieh Mahmoodi
  - Mani Ramzi
- PubMed: 41664386
- DOI: 10.4274/tjh.galenos.2026.09709
5 Insights on
- Reduced Vaso-Occlusive Crisis Frequency
- High evidence
- Clinical
the HU + L-glutamine group experienced significantly fewer VOCs (1.00±0.73 vs. 1.65±0.80; p=0.003)
Effect
Beneficial
Effect size
Large
Significant
Yes
Dose
not specified in abstract
Safety and efficacy of L-Glutamine in reducing the frequency of acute complications among patients with sickle cell disease: A randomized controlled study.
- 2024-07-19
- RCT
- Annals of hematology 103(9)
- - Fatma Soliman Elsayed Ebeid
  - Nihal Hussien Aly
  - Naglaa Mohammed Shaheen
  - Samah Mohammed Ahmed Abdellatif
  - Ahmed Ashraf Mahmoud Okba
  - Nada Ayman Gad
  - Sara Mostafa Makkeyah
- PubMed: 39028356
- DOI: 10.1007/s00277-024-05877-8
3 Insights on
- Reduced Vaso-Occlusive Crisis Frequency
- High evidence
- Clinical
a significantly lower cumulative number of VOCs ... in the glutamine group than in SOC (p=0.008, p<0.001 respectively)
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
0.3 gm/kg/dose/12h