L-Histidine and Reduced Confusion and Bewilderment

• Effects of a single dose of L-histidine on mental fatigue and vigor in participants with high fatigue levels: a randomized controlled trial.

  • 2026-04-15
  • RCT
  • Scientific reports 16(1)
  • • Masatsugu Shimomasuda
    • Haruna Fujiyoshi
    • Yu Kajiyama
    • Mayuka Kanda
    • Kenta Kajiwara
    • Kenji Nagao
    • Akira Abe
    • Shigekazu Kurihara
    • Hiroyuki Kato
    • Hidehiro Nakamura

  • PubMed: 41986440
  • DOI: 10.1038/s41598-026-48060-x

  9 Insights on

  • Reduced Confusion and Bewilderment

  • High evidence
  • Rigorous Journal
  • Adults

  In the all participants analysis set, the results did not show superiority of the L-histidine group over the placebo group for all endpoints.

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  single dose (exact amount not specified in abstract)