Short-term isolated leucine supplementation was not associated with improvements in muscle mass or function in patients with head and neck cancer: A randomized, double-blind, proof-of-concept trial with an elderly non-cancer comparator cohort.
- 2026-06
- RCT · n = 41
- Clinical nutrition ESPEN 73
- Márcia Fábia Andrade
- Gabriela Salim de Castro
- Silvio Pires Gomes
- Marcelo de Carvalho
- Joyce Cristina Ferreira de Resende
- Ivanir Pires
- Jaline Zandonato Faiad
- Ana Paula Noronha Barrère
- Ana Laura Camilo Venturini
- Rafael Souza
- Rafael De Cicco
- José Francisco de Gois Filho
- Bruna Franchi
- Everson Luiz Almeida Artifon
- José Pinhata Otoch
- Daniela Caetano Gonçalves
- Marília Seelaender
- PubMed: 41786247
- DOI: 10.1016/j.clnesp.2026.103100
- High evidence
- Clinical
Secondary outcomes, including muscle strength, gait speed, phase angle, and inflammatory markers, did not differ significantly between groups.
- Effect
- Neutral
- Effect size
- Small
- Significant
- No
- Dose
- 6 g/day