Systematic Review and Meta-Analysis of L-Methylfolate Augmentation in Depressive Disorders.
- 2021-11-18
- Meta-Analysis · n = 707
- Pharmacopsychiatry 55(03)
- Abdullah Al Maruf
- Ethan A Poweleit
- Lisa C Brown
- Jeffrey R Strawn
- Chad A Bousman
- PubMed: 34794190
- DOI: 10.1055/a-1681-2047
- High evidence
- Clinical
adjunctive L-methylfolate was associated with a small effect versus antidepressant monotherapy (relative risk: 1.25, 95% confidence interval [CI]=1.08 to 1.46, p=0.004)
- Effect
- Beneficial
- Effect size
- Moderate
- Significant
- Yes