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Evidence-Based Supplement Research

Evidence-Based Supplement Research

L-Methylfolate and Improved Delayed Memory

Doses used in studies

mg/day: 15 (median 15, IQR 15–15) — 2 studies

Time to effect

Median: 2.8 months · IQR 2.8 months–2.8 months · Range 2.8 months–2.8 months — Reported in 2 of 2 studies

Safety in these studies

Overall tolerabilityReported
L-Methylfolate was well tolerated
from: Does L-Methylfolate Supplement Methylphenidate Pharmacotherapy in Attention-Deficit/Hypera

2 of 2 papers

Biochemical, physiological and clinical effects of l-methylfolate in schizophrenia: a randomized controlled trial.
- 2017-03-14
- RCT · n = 55
- Molecular psychiatry 23(2)
- - J L Roffman
  - L J Petruzzi
  - A S Tanner
  - H E Brown
  - H Eryilmaz
  - N F Ho
  - M Giegold
  - N J Silverstein
  - T Bottiglieri
  - D S Manoach
  - J W Smoller
  - D C Henderson
  - D C Goff
- PubMed: 28289280
- DOI: 10.1038/mp.2017.41
5 Insights on
- Improved Delayed Memory
- High evidence
- Clinical
No treatment differences were seen in other symptom rating scales or cognitive composite scores.
Effect
Neutral
Effect size
Small
Significant
No
Dose
15 mg
Does L-Methylfolate Supplement Methylphenidate Pharmacotherapy in Attention-Deficit/Hyperactivity Disorder?: Evidence of Lack of Benefit From a Double-Blind, Placebo-Controlled, Randomized Clinical Trial.
- 2019-01
- RCT
- Journal of clinical psychopharmacology 39(1)
- - Craig Surman
  - Atilla Ceranoglu
  - Carrie Vaudreuil
  - Brittany Albright
  - Mai Uchida
  - Amy Yule
  - Andrea Spencer
  - Heidi Boland
  - Rebecca Grossman
  - Lauren Rhodewalt
  - Maura Fitzgerald
  - Joseph Biederman
- PubMed: 30566416
- DOI: 10.1097/jcp.0000000000000990
8 Insights on
- Improved Delayed Memory
- High evidence
- Clinical
no significant effect over placebo except improvement from abnormal measures on the mean adaptive dimension of the ASR scale
Effect
Neutral
Effect size
Small
Significant
No
Dose
15 mg