L-Methylfolate and Improved Positive and Negative Syndrome Scale Total Score

• Biochemical, physiological and clinical effects of l-methylfolate in schizophrenia: a randomized controlled trial.

  • 2017-03-14
  • RCT · n = 55
  • Molecular psychiatry 23(2)
  • • J L Roffman
    • L J Petruzzi
    • A S Tanner
    • H E Brown
    • H Eryilmaz
    • N F Ho
    • M Giegold
    • N J Silverstein
    • T Bottiglieri
    • D S Manoach
    • J W Smoller
    • D C Henderson
    • D C Goff

  • PubMed: 28289280
  • DOI: 10.1038/mp.2017.41

  5 Insights on

  • Improved Positive and Negative Syndrome Scale Total Score

  • High evidence
  • Clinical

  Compared with placebo, l-methylfolate increased plasma methylfolate levels (d=1.00, P=0.0009) and improved PANSS Total (d=0.61, P=0.03) as well as PANSS Negative and General Psychopathology subscales.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  15 mg