L-Methylfolate and Reduced Hepatic Venous Pressure Gradient

Time to effect

Median: 3 months · IQR 3 months–3 months · Range 3 months–3 months — Reported in 1 of 1 study

1 of 1 paper

5-MTHF enhances the portal pressure reduction achieved with propranolol in patients with cirrhosis: A randomized placebo-controlled trial.

2023-10
RCT
Journal of hepatology 79(4)
- Ranka Vukotic
- Roberto Di Donato
- Greta Roncarati
- Patrizia Simoni
- Matteo Renzulli
- Stefano Gitto
- Filippo Schepis
- Erica Villa
- Annalisa Berzigotti
- Jaume Bosch
- Pietro Andreone

PubMed: 37482222
DOI: 10.1016/j.jhep.2023.06.017

5 Insights on

Reduced Hepatic Venous Pressure Gradient

High evidence
Clinical

HVPG decreased in both groups, but the magnitude of the change was significantly greater in the group treated with 5-MTHF+propranolol compared to placebo+propranolol (percentage decrease, 20 [29-9] vs. 12.5 [22-0], p=0.028)

Effect: Beneficial
Effect size: Moderate
Significant: Yes