L-Methylfolate and Reduced Manic Symptoms

• L-Methylfolate For Bipolar I depressive episodes: An open trial proof-of-concept registry.

  • 2017-01
  • Clinical Trial · n = 10
  • Journal of affective disorders 207
  • • Andrew A Nierenberg
    • Rebecca Montana
    • Gustavo Kinrys
    • Thilo Deckersbach
    • Steven Dufour
    • Ji Hyun Baek

  • PubMed: 27794238
  • DOI: 10.1016/j.jad.2016.09.053

  2 Insights on

  • Reduced Manic Symptoms

  • Moderate evidence
  • Clinical

  The pre-treatment YMRS score was 3.2 (3.0); the post-treatment score was 2.7 (5.2). Cohen's d was 0.17.

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  15 mg/day