Does L-Methylfolate Supplement Methylphenidate Pharmacotherapy in Attention-Deficit/Hyperactivity Disorder?: Evidence of Lack of Benefit From a Double-Blind, Placebo-Controlled, Randomized Clinical Trial.
- 2019-01
- RCT
- Journal of clinical psychopharmacology 39(1)
- Craig Surman
- Atilla Ceranoglu
- Carrie Vaudreuil
- Brittany Albright
- Mai Uchida
- Amy Yule
- Andrea Spencer
- Heidi Boland
- Rebecca Grossman
- Lauren Rhodewalt
- Maura Fitzgerald
- Joseph Biederman
- PubMed: 30566416
- DOI: 10.1097/jcp.0000000000000990
- High evidence
- Clinical
Methylphenidate dosing was significantly higher in individuals on L-methylfolate over time (χ = 7.35, P = 0.007)
- Effect
- Harmful
- Effect size
- Small
- Significant
- Yes
- Dose
- 15 mg