L-Ornithine and Delayed Dim Light Melatonin Onset

• A randomized, double-blind and placebo-controlled crossover trial on the effect of l-ornithine ingestion on the human circadian clock.

  • 2018-07-03
  • RCT
  • Chronobiology international 35(10)
  • • Takafumi Fukuda
    • Atsushi Haraguchi
    • Masaki Takahashi
    • Takashi Nakaoka
    • Mayuko Fukazawa
    • Jin Okubo
    • Mamiho Ozaki
    • Ayana Kanatome
    • Rena Ohya
    • Yutaka Miura
    • Kuniaki Obara
    • Shigenobu Shibata

  • PubMed: 29969301
  • DOI: 10.1080/07420528.2018.1490315

  1 Insight on

  • Delayed Dim Light Melatonin Onset

  • High evidence
  • Adults

  dim light melatonin onset, a recognized marker of central circadian phase, was delayed by 15 min after ingestion of L-ornithine

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

  Dose

  400 mg per day