L-Selenomethionine and Increased Selenium Concentration in Tissue

• Selenium accumulation in prostate tissue during a randomized, controlled short-term trial of l-selenomethionine: a Southwest Oncology Group Study.

  • 2006-04-01
  • RCT · n = 34
  • Clinical cancer research : an official journal of the American Association for Cancer Research 12(7)
  • • Anita L Sabichi
    • J Jack Lee
    • Robert J Taylor
    • Ian M Thompson
    • Brian J Miles
    • Catherine M Tangen
    • Lori M Minasian
    • Louis L Pisters
    • John R Caton
    • Joseph W Basler
    • Seth P Lerner
    • David G Menter
    • James R Marshall
    • E David Crawford
    • Scott M Lippman

  • PubMed: 16609032
  • DOI: 10.1158/1078-0432.ccr-05-0937

  3 Insights on

  • Increased Selenium Concentration in Tissue

  • High evidence
  • Clinical

  The selenium concentration in prostate tissue was 22% higher in the SeMet arm ... 1.80 versus 1.47 ppm; P = 0.003, Wilcoxon rank sum test

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  not specified in abstract