L-Selenomethionine and Increased Selenium Level

• Selenium supplementation in the management of thyroid autoimmunity during pregnancy: results of the "SERENA study", a randomized, double-blind, placebo-controlled trial.

  • 2019-05-25
  • RCT
  • Endocrine 66(3)
  • • G Mantovani
    • A M Isidori
    • C Moretti
    • C Di Dato
    • E Greco
    • P Ciolli
    • M Bonomi
    • L Petrone
    • A Fumarola
    • G Campagna
    • G Vannucchi
    • S Di Sante
    • C Pozza
    • A Faggiano
    • A Lenzi
    • E Giannetta

  • PubMed: 31129812
  • DOI: 10.1007/s12020-019-01958-1

  11 Insights on

  • Increased Selenium Level

  • High evidence
  • Clinical

  A significant increase in selenemia was measured in L-Se-Met group at T2 (91.33 ± 25.49; p < 0.01) and PP (93.55 ± 23.53; p = 0.02)

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  83 mcg/day

• Selenium accumulation in prostate tissue during a randomized, controlled short-term trial of l-selenomethionine: a Southwest Oncology Group Study.

  • 2006-04-01
  • RCT · n = 34
  • Clinical cancer research : an official journal of the American Association for Cancer Research 12(7)
  • • Anita L Sabichi
    • J Jack Lee
    • Robert J Taylor
    • Ian M Thompson
    • Brian J Miles
    • Catherine M Tangen
    • Lori M Minasian
    • Louis L Pisters
    • John R Caton
    • Joseph W Basler
    • Seth P Lerner
    • David G Menter
    • James R Marshall
    • E David Crawford
    • Scott M Lippman

  • PubMed: 16609032
  • DOI: 10.1158/1078-0432.ccr-05-0937

  3 Insights on

  • Increased Selenium Level

  • High evidence
  • Clinical

  After the intervention, the mean serum selenium level increased 15% in the SeMet arm and was higher than in the observation arm (P = 0.001)

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

  Dose

  not specified in abstract