L-Serine and Improved Performance Mastery

• Potential benefits of l-serine in children with GRIN2B loss-of-function variants: Randomized n-of-1 trials.

  • 2025-12
  • RCT · n = 3
  • Molecular genetics and metabolism 146(4)
  • • Bibiche den Hollander
    • Marieke Rothuizen-Lindenschot
    • Hoang Lan Le
    • Jennifer R Ramautar
    • Annelieke R Müller
    • Lisa Geertjens
    • Frédéric M Vaz
    • Agnies M van Eeghen
    • Martina C Cornel
    • Bart A W Jacobs
    • Hilgo Bruining
    • Peter M van de Ven
    • Marion M Brands
    • Clara D van Karnebeek

  • PubMed: 41265180
  • DOI: 10.1016/j.ymgme.2025.109268

  1 Insight on

  • Improved Performance Mastery

  • High evidence
  • Clinical

  The Perceive, Recall, Plan, and Perform Assessment (PRPP-A) showed a significant improvement in Performance Mastery at 1.5 months (p = 0.0373)

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes