l-theanine adjunct to sertraline for major depressive disorder: A randomized, double-blind, placebo-controlled clinical trial.
- 2023-07
- RCT · n = 50
- Journal of affective disorders 333
- Ahmad Shamabadi
- Farnaz Kafi
- Melika Arab Bafrani
- Hassan Asadigandomani
- Fatemeh A Basti
- Shahin Akhondzadeh
- PubMed: 37084960
- DOI: 10.1016/j.jad.2023.04.029
- High evidence
- Clinical
All patients responded to sertraline plus l-theanine until week 6. l-theanine was superior to placebo regarding response to treatment and remission rates at week 6 (p-values = 0.05 and 0.02, respectively).
- Effect
- Beneficial
- Effect size
- Large
- Significant
- Yes
- Dose
- 200 mg/d