L-Tryptophan and Increased Blood Glucose Levels

• Effects of intragastric administration of L-tryptophan on the glycaemic response to a nutrient drink in men with type 2 diabetes - impacts on gastric emptying, glucoregulatory hormones and glucose absorption.

  • 2021-01-05
  • RCT
  • Nutrition & diabetes 11(1)
  • • Maryam Hajishafiee
    • Rachel A Elovaris
    • Karen L Jones
    • Leonie K Heilbronn
    • Michael Horowitz
    • Sally D Poppitt
    • Christine Feinle-Bisset

  • PubMed: 33414406
  • DOI: 10.1038/s41387-020-00146-9

  11 Insights on

  • Increased Blood Glucose Levels

  • High evidence
  • Clinical

  Plasma ... 3-OMG increased on all days, with no major differences between treatments

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  1.5 g ('Trp-1.5')

• Effects of Duodenal Infusion of Lauric Acid and L-Tryptophan, Alone and Combined, on Fasting Glucose, Insulin and Glucagon in Healthy Men.

  • 2019-11-07
  • RCT
  • Nutrients 11(11)
  • • Christina McVeay
    • Penelope C E Fitzgerald
    • Michael Horowitz
    • Christine Feinle-Bisset

  • PubMed: 31703434
  • DOI: 10.3390/nu11112697

  4 Insights on

  • Increased Blood Glucose Levels

  • High evidence
  • Rigorous Journal
  • Adults

  C12+Trp, but not C12 or Trp, stimulated insulin and increased the insulin-to-glucose ratio (p < 0.05).

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

  Dose

  0.1 kcal/min intraduodenal infusion in combination with 0.3 kcal/min Lauric Acid for 90 min