N-Acetyl Cysteine and Changed Functional Connectivity

Doses used in studies

mg/kg/week: 50 (median 50, IQR 50–50) — 1 study

Time to effect

Median: 6 months · IQR 6 months–6 months · Range 6 months–6 months — Reported in 1 of 1 study

1 of 1 paper

N-Acetylcysteine is associated with changes in functional connectivity in patients with Parkinson's disease.

2026-03
RCT
Parkinsonism & related disorders 144
- Daniel A Monti
- George Zabrecky
- Daniel Kremens
- Tsao-Wei Liang
- Nancy A Wintering
- Faezeh Vedaei
- Emily Navarreto
- Monisha Gupta
- Alicia Steinmetz
- Anthony J Bazzan
- Feroze Mohammed
- Andrew B Newberg

PubMed: 41619526
DOI: 10.1016/j.parkreldis.2026.108216

2 Insights on

Changed Functional Connectivity

High evidence
Clinical

There were significant differences in the NAC group compared to the control group in functional connectivity measures after NAC. Specifically, there was significantly different functional connectivity between basal ganglia structures and the precuneus, precentral gyrus, postcentral gyrus, and particularly the Rolandic operculum.

Effect: Beneficial
Effect size: Moderate
Significant: Yes
Dose: 50 mg/kg weekly IV + 500 mg twice per day oral