N-Acetyl Cysteine and Improved FEV1/FVC Ratio

• Network meta-analysis of pharmacological treatments for idiopathic pulmonary fibrosis: evaluating effects on lung function.

  • 2026-02-23
  • Systematic Review
  • Frontiers in pharmacology 17
  • • Yajie Yin
    • Xinhui Wu
    • Zhihao Liu
    • Yinru Luo
    • Mi Jing
    • Kefeng Jing
    • Qiuyuan Li
    • Fei Wang
    • Ju Huang

  • PubMed: 41808863
  • DOI: 10.3389/fphar.2026.1761899

  2 Insights on

  • Improved FEV1/FVC Ratio

  • High evidence
  • Clinical

  NAC combined with Roxithromycin (RXM) was the most effective intervention for improving Vital Capacity (VC) (SUCRA: 88.8%) and Forced Expiratory Volume in 1 s/Forced Vital Capacity (FEV1/FVC) (SUCRA: 97.45%).

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes