N-Acetyl Cysteine and Improved Recovery Rate

• COVID-19 clinical outcomes and N-acetylcysteine (CoViNAC study): a GRADE compliant meta-analysis of randomized controlled trials with molecular docking and dynamics simulation studies with Mpro of SARS-CoV-2.

  • 2025-05-26
  • Meta-Analysis · n = 1,125
  • Cellular and molecular biology (Noisy-le-Grand, France) 71(5)
  • • Seshadri Reddy Varikasuvu
    • Munikumar Manne
    • Subodh Kumar
    • Shiv Kumar Mudgal
    • Vikash Raj
    • Saurabh Varshney
    • Pratima Gupta
    • Ashoo Grover
    • Chanchal Goyal
    • Vanita Lal
    • Harminder Singh
    • Mona Lisa
    • Saransh Workshop Members

  • PubMed: 40418545
  • DOI: 10.14715/cmb/2025.71.5.13

  2 Insights on

  • Improved Recovery Rate

  • High evidence

  Six RCTs (656 patients) showed improved recovery/discharge rates (RR=1.09, 95% CI 1.03-1.14, p=0.003; I²=0%).

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

• N-Acetyl Cysteine in Rodenticide Poisoning: A Systematic Review and Meta-Analysis.

  • 2022-11
  • Meta-Analysis · n = 492
  • Current reviews in clinical and experimental pharmacology 17(3)
  • • Muhammed Rashid
    • Viji Pulikkel Chandran
    • Sreedharan Nair
    • Deepa Sudalai Muthu
    • Jemima Pappuraj
    • Krupa Ann Jacob
    • Balaji Sridhar
    • Karen Mark
    • Shabnam Hyder
    • Sohil Khan
    • Girish Thunga

  • PubMed: 34455951
  • DOI: 10.2174/2772432816666210825102726

  4 Insights on

  • Improved Recovery Rate

  • High evidence

  Pooled results of RCTs (n=2) showed a significant recovery rate (Odds Ratio [OR]: 3.97; 95% Confidence Interval [CI]:1.69-9.30)

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes