N-Acetyl Cysteine and Increased Total Thiol Level

Doses used in studies

mg/day: 1,200 (median 1,200, IQR 1,200–1,200) — 1 study

Time to effect

Median: 2.8 months · IQR 2.8 months–2.8 months · Range 2.8 months–2.8 months — Reported in 1 of 1 study

1 of 1 paper

A Pilot Study to Evaluate the Effects of Oral N-Acetyl Cysteine on Inflammatory and Oxidative Stress Biomarkers in Rheumatoid Arthritis.

2019-07-31
RCT · n = 23
Current rheumatology reviews 15(3)
- Ghazal Hashemi
- Mahtabalsadat Mirjalili
- Zahra Basiri
- Ahmad Tahamoli-Roudsari
- Nejat Kheiripour
- Maryam Shahdoust
- Akram Ranjbar
- Maryam Mehrpooya
- Sara Ataei

PubMed: 30255760
DOI: 10.2174/1573403x14666180926100811

10 Insights on

Increased Total Thiol Level

High evidence
Clinical

Results showed that in the NAC group, the serum levels of MDA, NO, IL-6, TNF-α, ESR and CRP were significantly lower than the baseline. Also, the serum level of TAC and TTG, as antioxidant parameters, increased significantly. However, only NO, MDA and TTG showed a significant difference in the NAC group as compared to the placebo group at the end of study.

Effect: Beneficial
Effect size: Small
Significant: Yes
Dose: 600 mg twice daily