N-Acetyl Cysteine and Reduced Anti-Tuberculosis Drug Induced Liver Injury

• Systematic review and network meta-analysis of efficacy and safety of interventions for preventing anti-tuberculosis drug induced liver injury.

  • 2023-11-14
  • Systematic Review · n = 3,423
  • Scientific reports 13(1)
  • • Pattaraporn Akkahadsee
    • Ratree Sawangjit
    • Panumart Phumart
    • Nathorn Chaiyakunapruk
    • Duangkamon Sakloetsakun

  • PubMed: 37963954
  • DOI: 10.1038/s41598-023-46565-3

  1 Insight on

  • Reduced Anti-Tuberculosis Drug Induced Liver Injury

  • High evidence
  • Rigorous Journal
  • Clinical

  N-acetyl cysteine (NAC) (RR 0.09; 95% CI 0.01 to 0.75) significantly reduced the incidence of anti-TB DILI compared with placebo

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes