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Evidence-Based Supplement Research

Evidence-Based Supplement Research

N-Acetyl Cysteine and Reduced Biofilm Formation

Doses used in studies

mg/day: 1,200 (median 1,200, IQR 1,200–1,200) — 1 study

Time to effect

Median: 5 weeks · IQR 5 weeks–5 weeks · Range 5 weeks–5 weeks — Reported in 1 of 2 studies

Safety in these studies

Overall tolerabilityReported
NAC was consistently rated safe and well-tolerated.
from: N-acetylcysteine: evidence based consensus document on the therapeutic advantages in respi
Overall tolerabilityReported
No significant treatment-emergent adverse effects (TEAEs) were observed in either group.
from: Efficacy and safety of N-acetylcysteine vs. probiotics in in-vivo biofilm prevention on ur

2 of 2 papersPopulation:

Efficacy and safety of N-acetylcysteine vs. probiotics in in-vivo biofilm prevention on ureteral stents: a prospective randomized controlled pilot in vivo study.
- 2025-08-11
- RCT
- International urology and nephrology 58(3)
- - Iqbal Singh
  - Himanshu Agrawal
  - Shailender Maurya
  - Himanshu Tanwar
  - Sanjay Gupta
  - N P Singh
- PubMed: 40788469
- DOI: 10.1007/s11255-025-04713-w
4 Insights on
- Reduced Biofilm Formation
- High evidence
- Clinical
Biofilm was absent in group I but was detected in 6.7% of group II.
Effect
Beneficial
Effect size
Large
Significant
Yes
Dose
600 mg twice daily
N-acetylcysteine: evidence based consensus document on the therapeutic advantages in respiratory diseases (NECTAR).
- 2026-05-04
- Review
- Frontiers in medicine 13
- - Monica Barne
  - Madhuragauri Shevade
  - Parthasarathi Bhattacharyya
  - Devasahayam J Christopher
  - Sanjeev Nair
  - Nitin Abhyankar
  - Indranil Halder
  - Agam Vora
  - Arjun Khanna
  - Rajesh Swarnakar
  - Prashant Chhajed
  - Balamurugan Santhalingam
  - Aishwarya Nair
  - Sundeep Salvi
- PubMed: 42158130
- DOI: 10.3389/fmed.2026.1810363
9 Insights on
- Reduced Biofilm Formation
- Low evidence
In CF, NAC improves lung function, mucociliary clearance, and disrupts biofilms.
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
low dose (not further specified)