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Evidence-Based Supplement Research

Evidence-Based Supplement Research

N-Acetyl Cysteine and Reduced C-Reactive Protein Levels

Doses used in studies

mg/day: 600 (median 600, IQR 600–600) — 1 study

Time to effect

Median: 8 weeks · IQR 8 weeks–8 weeks · Range 8 weeks–8 weeks — Reported in 1 of 2 studies

2 of 2 papersPopulation:

Co-administration of vitamin D and N-acetylcysteine to modulate immunosenescence in older adults with vitamin D deficiency: a randomized clinical trial.
- 2025-05-12
- RCT
- Frontiers in immunology 16
- - Samira Rastgoo
  - Katayoun Pourvali
  - Seyed Ahmad Raeissadat
  - Ghazaleh Eslamian
  - Hamid Zand
- PubMed: 40421021
- DOI: 10.3389/fimmu.2025.1570441
6 Insights on
- Reduced C-Reactive Protein Levels
- High evidence
- Clinical
No significant differences were observed between the groups in serum ... C-reactive protein (CRP) ... after the intervention.
Effect
Neutral
Effect size
Small
Significant
No
Dose
1000 IU daily
N-Acetyl-L-cysteine in human rheumatoid arthritis and its effects on nitric oxide (NO) and malondialdehyde (MDA): analytical and clinical considerations.
- 2022-07-13
- Review
- Amino acids 54(9)
- - Dimitrios Tsikas
  - Marie Mikuteit
- PubMed: 35829920
- DOI: 10.1007/s00726-022-03185-x
5 Insights on
- Reduced C-Reactive Protein Levels
- Low evidence
Reported data on NO, MDA and clinical parameters, including C-reactive protein, interleukins and tumour necrosis factor α, are contradictory in the literature.
Effect
Neutral
Effect size
Small
Significant
No